![]() These discoveries lead to Kaelin’s sharing the Nobel Prize in Physiology or Medicine in 2019. Kaelin Jr., Sidney Farber Professor of Medicine at HMS and Dana-Farber Cancer Institute and senior physician in medicine at Brigham and Women's Hospital, shows that cells lacking the VHL ( von Hippel-Laudau) gene and its associated protein are incapable of sensing oxygen and later shows that these cells are unable to degrade HIF-1-alpha, a master regulator of the cellular response to low oxygen levels. Celebrating 50 Years of Diversity and Inclusion.Research Departments, Centers, Initiatives and more.
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